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Volatile organic compounds (VOCs) in exhaled breath, sweat or urine carry much information on the state of human health. The role of VOCs in clinical diagnosis and therapeutic monitoring is expected to become increasingly significant due to recent advances in the field. Volatile Biomarkers: Non-Invasive Diagnosis in Physiology and Medicine includes the latest discoveries and applications for VOCs from the world's foremost scientists and clinicians working in this emerging analytic area.
- Appeals to a multidisciplinary audience, including scientists, researchers, and clinicians with an interest in breath analysis
- Features the latest scientific research and technical breakthroughs in the diagnostic and therapeutic aspects of volatile organic compounds
- Includes case presentations documenting applications in multiple areas of human health and safety
- Sales Rank: #3226915 in Books
- Published on: 2013-05-27
- Original language: English
- Number of items: 1
- Dimensions: 9.30" h x 1.20" w x 7.70" l, .0 pounds
- Binding: Hardcover
- 600 pages
Review
"The book appropriately starts with a discussion of interpreting breath analyses, and readers quickly learn that the lack of standardization for specimen collection, patient preparation, or laboratory analytical methodology has greatly limited its applicability to assessing human health or disease…This book nicely summarizes the current state of the art of VOC detection and analysis for a variety of interesting applications." --Doody.com, November 2013
"Volatile organic compounds are continuously generated by the human body and partially emitted in exhaled breath and through the skin, as well as other pathways…Medical, biological, chemical, and engineering specialists review developments in breath analysis since 2005, when the previous volume was completed." --Reference & Research Book News, October 2013
From the Back Cover
Volatile Biomarkers: Non-Invasive Diagnosis in Physiology and Medicine provides a comprehensive review of the use of volatile organic compounds (VOCs) generated through normal physiology or pathophysiology that are present as biomarkers in exhaled breath, other bodily excretions, and emitted via skin. These volatile metabolites carry valuable information on the metabolic status or disease activity in healthy people and patients alike. Their role in clinical diagnosis, therapy, and safety is an emerging multidisciplinary area of study that shows great promise for non-invasive and low-cost point-of-care monitoring of many common diseases such as cancer, respiratory and gastrointestinal dysfunction, nutritional intolerance and metabolic disorders, including diabetes.
This book:
- Gives first-hand accounts of discoveries and the potential significance of VOC metabolites by the world’s foremost scientists and clinicians in the field and synthesizes the growing literature in this area.
- Features the latest scientific research and technical breakthroughs in the diagnostic and therapeutic aspects of VOCs.
- Includes information on the latest instrumentation and technology such as proton transfer reaction- and selected ion flow tube-mass spectrometry (PTR-MS and SIFT-MS) and electronic noses, and provides examples of their potential significance in clinical diagnosis.
- Includes case presentations documenting the role of volatile biomarkers in many areas of human health and safety.
- Includes suggested models for standardizing sample collection and highlights new ways of identifying and quantifying VOCs in exhaled breath.
- Reviews endogenous volatiles in exhaled breath and those emitted by other biological media that are potential biomarkers for diseases such as cancer and diabetes.
About the Author
Prof. Dr. Anton Amann is Director of the Breath Research Institute of the Austrian Academy of Sciences and Professor at Innsbruck Medical University. He is a recipient of the prestigious Marie Sklodowska Curie Medal of the Polish Chemical Society. Prof. Amann coordinated the EU-project BAMOD (topic: breath analysis of lung carcinoma patients, eu-proposal.voc-research.at) and is a steering committee member of the EU-project SGL for USaR (topic: searching of entrapped persons, e.g., using volatile compounds released through breath, skin and urine, www.sgl-eu.org). He is Editor-in-Chief of the Journal of Breath Research, which is published by the “Institute of Physics” (IOP, Bristol, UK, www.iop.org/EJ/journal/JBR) and Chairman of the International Association for Breath Research (IABR, iabr.voc-research.at).
Prof. Dr. David Smith is Professor in the School of Medicine at Keele University (UK). He is a Fellow of the Royal Society (elected 1988) and a Fellow of the Institute of Physics. He was awarded the Schrödinger Prize in 1992. Prof. Smith is the inventor of Selected Ion Flow Tube Mass Spectrometry (SIFT-MS) and Flowing Afterglow Mass Spectrometry (FA-MS), now widely used for trace gas analysis of air and exhaled breath. He is co-author of more than 390 peer-reviewed papers and book chapters, covering the fields of plasma physics, ion chemistry, terrestrial and interstellar chemistry, mass spectrometry, gas analysis, and breath analysis (more than 12600 citations in Web of Science; h-index 61). He is Founder Member of the Editorial Board of the Journal of Breath Research.
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